Antiobesity Activity of Iles-Iles (Amorphophallus onchophyllus) Tuber Flour in Obesity Rat Model

Abstract

Obesity is a condition that occurs when the quantity of body fat tissue is greater
than the total body weight than normal, or the body experiences excess fat
accumulation which causes a person's weight to be far above normal. Obesity occurs
because the imbalance between energy from food intake is greater than the energy
used by the body. Iles-iles tuber plant from the Araceae tribe is one of the plants
used as natural medicine because the nature of the plant can cause physiological
activities in the human body. The purpose of this study was to determine the anti-
obesity activity of Iles-iles tuber flour (Amorphophallus onchophyllus) in a model of
obese Wistar rats. Iles-iles tubers contain glucomannan which is used for treatment.
A total of 25 male Wistar rats were divided into 5 groups consisting of negative
given 1% PGS, positive control group was given orlistat 15.6 mg/kg.BW, and 3
treatment groups were given extracts. iles-iles tuber flour doses of 25, 50, and 100
mg/kg.BW for 14 days. Previously, an increase in body mass was carried out to
become obese for 21 days and then observed changes in body weight and body
length of rats for 14 days, the results of which were used to calculate the Lee index.
The results showed that there was no significant difference between day 21 and day
35 in all groups with a significance of p>0.05.